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The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. It is at least as effective as the older antidepressants for treating mild to severe depression. Many clinicians consider mirtazapine a second-line or even third-line antidepressant to be used when older antidepressants are not tolerated or are ineffective. It is particularly useful in patients who experience sexual side effects from other antidepressants. Many clinicians consider mirtazapine a second-line or even third-line antidepressant, to be used when older antidepressants are not tolerated or are ineffective.

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Clearance of the drug is diminished in the presence of liver or renal impairment. This incidence is no higher than the incidence of other antidepressants. Double blind crossover study of mirtazapine, amitriptyline and placebo in patients with major depression. Mirtazapine is more effective than trazadone: a double-blind controlled study in hospitalized patients with major depression. Pharmacokinetic drug interactions of new antidepressants: a review of the effects on the metabolism of other drugs. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. As a result, symptoms of depression may become worse or motor skills may be affected. Alcohol is also known to interfere with rationality, occasionally causing people to act in ways they would not ever consider when sober.

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If you already suffer from depression, alcohol may make the condition worse. Alcohol also affects rational thinking, sometimes leading to behavior that is totally different from sober behavior. Those who drink heavily for a long period of time may be more prone to mood disorders, although it can be unclear as to whether the disorder existed prior to the drinking and led to heavy alcohol consumption or whether the alcohol brought on the condition. So someone who is already suffering from depression and anxiety is going to feel even worse the day after they drink.

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The main side effects include drowsiness (especially at lower doses), dizziness, anxiousness, confusion, increased appetite, increased weight, dry mouth, constipation, nausea and vomiting. The healthcare provider may increase the dosage if symptoms continue, or decrease the dose if side effects occur. It can also help insomnia, but unlike most medications, the low dose causes drowsiness. Other ways to help find depression include exercising, yoga, getting plenty of sleep, improving eating habits, and socializing. A diet high in fiber and low in fats, such as one filled with vegetables and fruits, can reduce depression. If you forget to take your evening dose you should just leave out that dose and take your morning and evening doses as usual the next day.

On very rare occasions some people have experienced withdrawal symptoms after accidentally missing a dose of mirtazapine. If you feel your depression has got worse, or if you have any distressing thoughts or feelings in these first few weeks, then you should talk to your doctor. If you are affected this is most likely to occur within the first few weeks of treatment. Consult your doctor if you experience yellowing of the eyes or skin, or darkened urine while taking mirtazapine, as these may be signs of jaundice. People with heart disease, eg abnormal heartbeats (arrhythmias), angina or recent heart attack. Mirtazapine may alter the control of your blood sugar.

However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. If your doctor decides that you should continue taking mirtazapine during your pregnancy the baby should be monitored for possible withdrawal effects if you keep taking the medicine up until the birth. If your doctor says you can continue taking mirtazapine while you are breastfeeding the baby should be monitored for possible side effects, such as drowsiness, poor feeding, irritability or changes in behaviour. This may involve symptoms such as a fever, sweating, increased heart rate, diarrhoea, shivering, uncontrollable muscle contractions, mood changes, restlessness, increased salivation and unconsciousness.

When they are bound to nerve cells in the brain, they no longer have an effect on mood. However, if you are taking a high dose your doctor may ask you to split this and take one dose in the morning and the other dose before going to bed. If you are affected this is most likely to occur within the first few weeks of treatment. It's trail and error finding the right medication that is the "key"to fixing us.