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The most notable potential benefit is that a single dose of ibogaine could lead to long-term suppression of opiate/opioid cravings such that former opiate/opioid users are able to maintain abstinence for an indefinite duration. Most individuals report substantial suppression or reduction of opiate/opioid cravings in the days and/or weeks after ibogaine administration – as compared to pre-treatment. Moreover, even after noribogaine metabolites have been cleared from systemic circulation, favorable neuroadaptive changes that are conducive to opiate/opioid abstinence are thought to linger. While using ibogaine without medical supervision is not recommended, anyone who does so could save a significant amount of money compared to conventional treatments for opiate/opioid addiction and the corresponding medical bills.

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The net decrease in reward center activity after ibogaine administration means that most recipients will not be motivated to abuse or become addicted to it. Assuming you’re addicted to other substances besides opiates/opioids, it may be possible to overcome all of your addictions simultaneously with ibogaine treatment. Moreover, even when conventional interventions are combined with psychotherapy, outpatient sobriety programs, and/or lifestyle changes – a subset of individuals will derive insignificant benefit, and predictably, will relapse whereby they revert back to illicit opiate/opioid administration. Although cognitive deficits resulting from ibogaine are transient, they may persist for weeks or months after treatment. Considering that ibogaine usage could prove fatal, this may be reason enough to avoid it. Hallucinogen persisting perceptual disorder is a condition characterized by permanent (or protracted) alterations in perceptions of sensory information following the administration of a hallucinogenic agent.

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While some may derive good return on investment from the ibogaine treatment as a result of protracted opiate/opioid abstinence (saving in spending on opiates/opioids and/or bolstered occupational productivity), others will find ibogaine clinics to be downright unaffordable. Anyone who uses ibogaine along with another substance may be at risk of experiencing severe interaction effects, which could result in permanent physiologic damage and/or death. It’s also necessary to mention that ibogaine plus another substance may significantly increase renal burden such that nephrotoxicity occurs. If caught in possession or under the influence of ibogaine by law enforcement, you may receive a hefty fine and a lengthy prison sentence.

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These complications may last for weeks, months, or in rare cases, indefinitely after ibogaine treatment. Moreover, considering the possibility of mania from ibogaine, persons with bipolar disorder may be suboptimal candidates for ibogaine treatment due to preexisting susceptibility. This excitotoxicity yields neuronal death and regional degeneration, and may produce long-term deficits in motor function associated with the head and upper extremities. Though some ibogaine users won’t mind psychotomimetic effects, others will dislike them and/or have trouble coping with them. It was further noted that the patient’s first psychotic episode occurred after the initiation of ibogaine usage. Some may claim that their cravings only remain suppressed for a short-term such as a few days or weeks – after ibogaine administration.

While most will find the side effects of ibogaine to be tolerable and manageable, others may dislike ibogaine’s side effect profile, especially when compared to opiate/opioid replacement therapies. Moreover, there are a myriad of other pharmaceutical medications such as clonidine and gabapentin that have stronger evidence to support their usage in the treatment of opiate/opioid withdrawal symptoms – as compared to ibogaine. After the single dose or series of doses, most responders to ibogaine will experience protracted suppression of opiate/opioid cravings and/or withdrawal symptoms. Others have reported using small doses of ibogaine on a daily basis to avert its psychedelic effect and for an ongoing anti-addiction effect. That said, it’s possible that one specific mechanism or multiple mechanisms of ibogaine’s and/or noribogaine’s action is of greater therapeutic relevance than others for the treatment of opiate/opioid addiction and/or discontinuation symptoms. Because antinociceptive effects of morphine are mediated by the mu-opioid receptor, it’s possible that ibogaine’s short-lived interaction with the mu-opioid receptor yields neurochemical changes that reduce or reverse preexisting opiate/opioid tolerance. In other words, someone who administered a kappa-opioid agonist followed by an opiate/opioid would probably derive less reward (or perhaps no reward) from the opiate/opioid.