Mirtazapine brand name – Mirtazapine Tablets FDA prescribing information, side effects and uses
In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. I (effectively) use the remeron as an antidepressant and try to take it nightly, even if that means mixing. This could lead to hepatoxicity (liver damage) and possibly neurotoxicity (brain damage). I searched the web and have found a few varied answers and a few trip reports but that's about it. Sure there's a lot of room for discourse over such a totally subjective experience, but sometimes it helps to exclude statistical outliers and get down to brass tacks.
Mirtazapine (Remeron) Side Effects, Dosage, Interactions Drugs
Mirtazapine increases noradrenergic and serotonergic transmission, as measured by on-line microdialysis and by enhancement of noradrenergic locus ceruleus and serotonergic raphe nucleus cell firing. The enhancement of both noradrenergic and serotonergic transmission probably underlies the therapeutic activity of mirtazapine. Subjectively, mirtazapine induced an improvement of sleep. In the maze test, mirtazapine shortened the food finding time (it improved memory) and counteracted memory loss induced by scopolamine. Moreover, citalopram still inhibited, and mirtazapine still failed to influence, dorsal raphe serotonergic neurons.
What happens if you overdose on Mirtazapine? o Answers
In rats chronically treated with imipramine or mirtazapine this effect was completely antagonized. These results demonstrate that long-term treatment with either imipramine or mirtazapine reduces the sensitivity of cortical cholinergic neurons to stress or to an anxiogenic drug with an efficacy similar to that of acute administration of benzodiazepines. Because dopaminergic transmission in the prefrontal cortex is sensitive to anxiogenic or stressful stimuli, the effects of two antidepressant drugs with different mechanisms of action, imipramine and mirtazapine, on the response of rat cortical dopaminergic neurons to stress were investigated. Long-term administration of imipramine or mirtazapine had no marked effect on the stress-induced increases in the brain or plasma concentrations of neuroactive steroids or corticosterone. The most important finding of this study is the significant differential response to the diazepam test: depressive patients with high trait anxiety showed, predominantly, a disappearance of depressive symptoms without sedation and depressive patients with low trait anxiety showed, predominantly, sedation without disappearance of depressive symptoms. In depressed patients, mirtazapine produces a significant shortening of sleep-onset latency, increases a total sleep time, and leads to a marked improvement in sleep efficiency.
Hooked on Mirtazapine: Addiction to Antidepressants
Mirtazepine is a potential alternative anti-depressant with multiple additional benefits. The positive predictive value of an early improvement was significantly higher during mirtazapine treatment compared with paroxetine. Mirtazapine was consistently superior to placebo, and equivalent in efficacy to the tricyclic antidepressants amitriptyline, doxepin and clomipramine, but with an improved tolerability profile. In addition, mirtazapine does not appear to be associated with sexual dysfunction.
There was no significant effect on rapid eye movement sleep variables. Mirtazapine in fixed and ascending nocturnal dosing regimens was found to facilitate sleep, but it does not generally reduce daytime alertness. Mirtazapine did not significantly alter rapid eye movement sleep parameters. The available data show that mirtazapine is superior to placebo in depressed patients with high baseline anxiety and/or agitation. Mirtazapine provides early and effective relief of both depressive and anxiety symptoms, reducing the need for polypharmacy.
The evaluation of the safety was based on data from all patients who took at least one dose of study medication during studies comparing mirtazapine with placebo, amitriptyline or other active comparators. These complaints were typically mild and transient in nature, and decreased over time despite increased doses of mirtazapine. The low seizure-inducing potential combined with a lack of cardiotoxic properties allows safety in an overdose of mirtazapine, even in elderly patients. Weight gain is the most commonly reported side-effect of mirtazapine, although there is evidence to suggest that this is not a significant problem during long-term treatment. However, the different pharmacologic profile of mirtazapine is reflected in its different tolerability profile. Among antidepressants, amitriptyline and mirtazapine are known to cause weight gain.
Mirtazapine also appears to be associated with a low rate of sexual adverse effects. In a comparison between mirtazapine and fluoxetine, initial treatment with fluoxetine is less expensive with respect to direct cost, but these two alternatives are equivalent when indirect costs are taken into consideration. Additionally, we want it to investigate the effects of different antidepressant medication (mirtazapine, venlafaxine, tianeptine and escitalopram) on oxidative status of depressed patients. Also, it seems that sub-classifying depression into different subtypes, based on chronicity, can predict differences in the levels of some various oxidative stress markers. Included studies had an open label phase in which an initial antidepressant was used for the treatment of major depression and a double blind phase for the incomplete responders that compared monotherapy with the first antidepressant versus the association of a second antidepressant to the first one. Mirtazapine is an atypical antidepressant receiving attention for substance abuse pharmacotherapy, and its action includes alterations in monoaminergic transmission. Collectively, these results indicate that mirtazapine may help to maintain abstinence in opioid dependent patients.