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When deciding whether or not to take mirtazapine during pregnancy it is important to weigh up how necessary mirtazapine is to your health against the possible risks to you or your baby, some of which will depend on how many weeks pregnant you are. Do not use more than the recommended dose of mirtazapine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. When bound to these nerve cells, they cannot affect mood. In healthy people, serotonin and noradrenaline would bind these receptors, but mirtazapine stops them from binding with the nerve cells. This is because alcohol impacts the same chemicals within the brain as mirtazapine, but does so differently. Both alcohol and mirtazapine can slow down your reaction time. This means that you can occasionally take mirtazapine and alcohol, but should only do so in moderation and on rare occasions.
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I wouldn't recommend using amphetamines to counteract the mirtazapine. This is because alcohol and medicines like mirtazapine affect similar chemicals in the brain. Most people experience drowsiness while taking mirtazapine, and alcohol makes this symptom worse. Also, as mentioned, a person should learn the effects of mirtazapine on their body before they begin drinking. None of those studies involved the antidepressant medication mirtazapine.
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No subjects reported serious adverse events all adverse events related to mirtazapine were reported to be minimal to moderate. Mirtazapine was better tolerated than amitriptyline. Mirtazapine demonstrated a large effect size for treating depression and a moderate effect size for treating alcohol craving. There were no serious adverse events during the study.
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Mirtazapine was well tolerated our subjects with comorbid major depressive disorder and alcohol dependence. However, those two previous studies did not evaluate the level of alcohol use during the course of their studies, though they both reported a significant decrease in level of alcohol craving during the course of their studies. Therefore, we believe that our current study is the first study to report a significant decrease in level of drinking in a comorbid major depressive disorder/alcohol dependence population treated with mirtazapine. It is thought that when depression occurs, there may be a decreased amount of noradrenaline and serotonin released from nerve cells in the brain. Noradrenaline and serotonin would normally bind to these receptors.
This enhances the mood-lightening effect of free noradrenaline and serotonin that is released from nerve cells, and helps relieve depression. Mirtazapine is usually taken once a day at bedtime. Mirtazapine can be taken either with or without food. On very rare occasions some people have experienced withdrawal symptoms after accidentally missing a dose of mirtazapine. If you feel your depression has got worse, or if you have any distressing thoughts or feelings in these first few weeks, then you should talk to your doctor.
Mirtazapine may cause dizziness, sleepiness and reduced concentration. You should avoid drinking alcohol while taking mirtazapine, as it will increase the risk of drowsiness and sedation. Consult your doctor if you experience yellowing of the eyes or skin, or darkened urine while taking mirtazapine, as these may be signs of jaundice. Mirtazapine tablets that dissolve on the tongue may contain aspartame, which is a source of phenylalanine. People with heart disease, eg abnormal heartbeats (arrhythmias), angina or recent heart attack. Mirtazapine may alter the control of your blood sugar. You should consult your doctor for advice straight away if you think you could be pregnant while taking mirtazapine.
Mirtazapine passes into breast milk in small amounts. The following are some of the side effects that are known to be associated with mirtazapine. You should let your doctor know if you experience any signs of infection while taking mirtazapine, for example flu-like symptoms, high temperature (fever), sore throat or mouth ulcers, so that your blood can be tested. If you experience seizures or fits while taking mirtazapine, consult your doctor immediately, as you may need to stop treatment. This may involve symptoms such as a fever, sweating, increased heart rate, diarrhoea, shivering, uncontrollable muscle contractions, mood changes, restlessness, increased salivation and unconsciousness. Similarly, check with your doctor or pharmacist before taking any new medicines while taking mirtazapine, to make sure that the combination is safe. The following medicines may increase the blood level of mirtazapine and could increase the risk of its side effects.