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I (effectively) use the remeron as an antidepressant and try to take it nightly, even if that means mixing. This could lead to hepatoxicity (liver damage) and possibly neurotoxicity (brain damage). I searched the web and have found a few varied answers and a few trip reports but that's about it. Sure there's a lot of room for discourse over such a totally subjective experience, but sometimes it helps to exclude statistical outliers and get down to brass tacks.
What is Mirtazapine (Remeron)? An Anti Addiction Medication for Cravings
A double-blind study comparing the efficacy and tolerability of mirtazapine and doxepin in patients with major depression. Review of the results from clinical studies on the efficacy, safety and tolerability of mirtazapine for the treatment of patients with major depression. Mirtazapine-associated dose-dependent and asymptomatic elevation of hepatic enzymes. Mirtazapine-induced hepatocellular-type liver injury. Mirtazapine has a tetracyclic chemical structure and belongs to the piperazino-azepine group of compounds. Elimination of mirtazapine is correlated with creatinine clearance. Relapse during the double-blind phase was determined by the individual investigators.
Pharmacokinetics of mirtazapine and its main metabolites after single intravenous and oral administrations in rats at two dose rates DARU Journal of Pharmaceutical Sciences Full Text
The drowsiness associated with mirtazapine use may impair a patient’s ability to drive, use machines, or perform tasks that require alertness. Mirtazapine did not significantly affect the pharmacokinetics of phenytoin. If treatment with such a medicinal product is discontinued, it may be necessary to reduce the mirtazapine dose. Mirtazapine did not cause relevant changes in the pharmacokinetics of cimetidine.
Extractive Spectrophotometric Determination of Mirtazapine in Pure and Pharmaceutical Forms : Oriental Journal of Chemistry
The effects of higher doses of lithium on the pharmacokinetics of mirtazapine are unknown. However, in rats, there was an increase in postimplantation losses in dams treated with mirtazapine. The conditions and duration of exposure to mirtazapine varied greatly, and included (in overlapping categories) open and double-blind studies, uncontrolled and controlled studies, inpatient and outpatient studies, fixed-dose and titration studies. There is no experience with the use of forced diuresis, dialysis, hemoperfusion, or exchange transfusion in the treatment of mirtazapine overdosage. Some mirtazapine may pass into your breast milk. When we think of drug addiction we tend to imagine hidden bottles of alcohol, hypodermic needles, and crack pipes. A heroin addict compulsively seeks heroin’s powerful effect on the brain not only because of the physically dependence that is associated with it but also because of the intense pleasure that the drug brings the user.
If somebody tried to abruptly stop taking the drug after prolonged use, the resulting withdrawal would be so intense that they would likely not be able to bear it. It has been shown to be able to treat a wide range of various mental and mood disorders in addition to low appetite and insomnia very effectively. While it is not unusual to experience these side effects, they can be unpredictable and seemingly random in their occurrence. Blood samples were collected as for study one. The low oral bioavailability value found in the current study is noteworthy. Mirtazapine is a moderate peripheral adrenergic antagonist, a property that explains the occasional othostatic hypotension reported in association with its use. Different solutions of drug in the range of calibration curve were chosen and the assay was estimated using the calibration curve.
The reagent blank under similar conditions showed no absorption. Chiral liquid chromatographic determination of mirtazapine in human plasma using two-phase liquid-phase microextraction for sample preparation. Mirtazapine in pure and dosage form was applied in this study. Selective blockade of specific serotonin receptors by mirtazapine likey minimizes side effects typical of other antidepressants. The drowsiness associated with mirtazapine use may impair a patientí s ability to drive, use machines or perform tasks that require alertness. The effects of mirtazapine on the interactions between central noradrenergic and serotonergic systems. Mirtazapine: clinical advantages in the treatment of depression.
Public health advisory: suicidality in children and adolescents being treated with antidepressant medications. Many clinicians consider mirtazapine a second-line or even third-line antidepressant to be used when older antidepressants are not tolerated or are ineffective. It affects chemicals in the brain that may become unbalanced and cause depression. Nowadays, people are increasingly began to buy pills online pharmacies, as it is cheap, convenient, fast and reliable.